Pemphigus vulgaris possibly triggered by Cilazapril.

Sir, Cilazapril is a new angiotensin converting enzyme inhibitor (ACEI) which, like other ACEIs, is a non-thiol molecule, containing an active amide group. Since the early 1990s an increasing number of case reports have been published pointing to the role of this family of drugs in inducing or triggering pemphigus (1). In 1992, the ACEI Enalapril was found to be the most powerful acantholytic drug in vitro (2). Buzon et al. (3) reported the ®rst case of pemphigus foliaceous associated with Cilazapril. We describe here the possible association of the drug with pemphigus vulgaris.